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Alice Loo Selected Research

2- (2- (3,5- difluorophenyl)- 2- hydroxyacetamido)- N- (3- methyl- 4- oxo- 4,5- dihydro- 3H- benzo(d)(1,2)diazepin- 5- yl)propanamide

7/2007Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.

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Alice Loo Research Topics

Disease

12Neoplasms (Cancer)
01/2021 - 09/2008
2Colorectal Neoplasms (Colorectal Cancer)
01/2021 - 10/2011
2Breast Neoplasms (Breast Cancer)
10/2018 - 01/2017
1Lung Neoplasms (Lung Cancer)
01/2021
1Ovarian Neoplasms (Ovarian Cancer)
10/2020
1Glioblastoma (Glioblastoma Multiforme)
01/2020
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
01/2018
1Philadelphia Chromosome
01/2017
1Retinoblastoma (Glioblastoma, Retinal)
09/2014
1Liposarcoma
09/2014
1Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
10/2011
1Adenocarcinoma
10/2011
1Oncogene Addiction
10/2011
1B-Cell Lymphoma (Lymphoma, B Cell)
04/2011
1Multiple Myeloma
07/2010
1Alzheimer Disease (Alzheimer's Disease)
07/2007

Drug/Important Bio-Agent (IBA)

4ribociclibIBA
01/2021 - 09/2014
4Small Interfering RNA (siRNA)IBA
09/2014 - 09/2008
3Cyclin-Dependent Kinases (cdk Proteins)IBA
04/2020 - 10/2018
3Pharmaceutical PreparationsIBA
01/2020 - 02/2009
2Protein Isoforms (Isoforms)IBA
01/2021 - 09/2008
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2021 - 05/2009
2Hormones (Hormone)IBA
01/2020 - 10/2018
2Oncogene Proteins (Oncogene Protein)IBA
01/2018 - 10/2011
2Proteins (Proteins, Gene)FDA Link
06/2013 - 09/2008
2Polycomb-Group ProteinsIBA
07/2010 - 02/2009
1nazartinibIBA
01/2021
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2021
1Biomarkers (Surrogate Marker)IBA
10/2020
1Chloroquine (Aralen)FDA LinkGeneric
01/2020
1Lu 28-179 (Siramesine)IBA
01/2020
1Anti-Bacterial Agents (Antibiotics)IBA
01/2020
1Antidepressive Agents (Antidepressants)IBA
01/2020
1Azithromycin (Zithromax)FDA LinkGeneric
01/2020
1ErbB Receptors (EGF Receptor)IBA
10/2018
1Aromatase InhibitorsIBA
10/2018
1acrylic acid (acrylate)IBA
01/2017
11,2,3,4-tetrahydroisoquinolineIBA
01/2017
1Estrogen ReceptorsIBA
01/2017
1asciminibIBA
01/2017
1Bromodeoxyuridine (BrdU)IBA
09/2014
1Tumor Biomarkers (Tumor Markers)IBA
09/2014
1Molecular Chaperones (Chaperone, Molecular)IBA
06/2013
1Heat-Shock Proteins (Heat-Shock Protein)IBA
06/2013
1CateninsIBA
10/2011
1Differentiation AntigensIBA
10/2011
1beta CateninIBA
10/2011
1Protein Kinase CIBA
04/2011
1sotrastaurinIBA
04/2011
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
09/2008
1LipidsIBA
09/2008
1Phosphotransferases (Kinase)IBA
09/2008
12- (2- (3,5- difluorophenyl)- 2- hydroxyacetamido)- N- (3- methyl- 4- oxo- 4,5- dihydro- 3H- benzo(d)(1,2)diazepin- 5- yl)propanamideIBA
07/2007
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
07/2007

Therapy/Procedure

5Therapeutics
01/2021 - 05/2009
1Drug Therapy (Chemotherapy)
10/2020
1Oral Administration
09/2014